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Research in the Pharmaceutical Sciences

Contributions to the Knowledge of Science

The Department of Pharmaceutical Sciences is continuously successful in obtaining external funding to support the research and scholarship of the faculty. Recently, two new laboratories have been constructed, one devoted to research in molecular pharmacology and one to pharmaceutical formulation studies.

The labs are equipped with modern instrumentation, including:

Formulations and Drug Stability
  • High performance liquid chromatography (HPLC) (Shimadzu)
  • UV/VIS spectroscopy (Cary 50)
  • Thermogravimetric Analysis (TGA) (TA Instruments)
  • Differential Scanning Calorimeter (DSC) (TA Instruments)
  • X-Ray Diffractometer (Bruker)
  • Moisture Sorption/Desorption Analyzer (TA Instruments)
  • Particle Size Analysis and Processing (Horiba)
  • USP Dissolution apparatus with Optic Fibers (Distek)
  • USP Dissolution apparatus (Vankel)
  • Incubator (Fisher Scientific)
  • Stability Chambers (Thermo Scientific)
  • Natoli Tablet Press
  • Rotary (ten-station) Tablet Press (SMI Piccola)
  • Diosna Wet Granulator
  • Retsch Ball Mill
  • Rotary Solvent Evaporator (buchi)
  • Twin Shell Dry Blender (PK)
  • Quadro Comil
  • Tap Density Apparatus (Varian)
  • Bulk Density Apparatus (Scott Volumeter)
  • Sonic Sifter (Advantech)
  • Sieve Shaker (Rotap)
  • Tablet Friabilator (Varian)
  • Tablet Hardness Tester (Varian)
  • Tablet Disintegration Tester (Varian)
  • True Density Pycnometer (Micromeritics)
  • Buchi Spray Dryer
  • VirTis Lyophilizer (SP Scientific)
  • pH Meter (mettler Toledo)
  • Heratherm Oven (Thermo Scientific)
  • Incubator Shaker (New Brunswick Scientific)
  • Unuator (CITO)
  • Ointment Mill (EXAKT)
  • Milli-Q Purified Water System (Millipore)
Molecular Pharmacology and Cell Biology
  • SpectraMax Microplate Reader for visible, fluorescent, and chemiluminescence assays
  • Applied Biosystems StepOne Real-Time Quantitative PCR System
  • BioRad MyCycler Thermal Cycler for PCR
  • Zeiss fluorescence and visible light microscope with AxioVision analysis software
  • BioRad MiniProtean Tetra Western Blotting System
  • Kodak imaging system for gel electrophoresis
  • BioRad VersaDoc imaging system for immunoblot analyses
  • Thermo Scientific NanoDrop Spectrophotometer
  • Cell culture CO2 incubators and sterile biosafety hood
  • Low temperature (-80° C and liquid N2) storage
  • Refrigerated centrifuges for large and small volumes
  • Autoclave

Additional facilities, such as gas chromatography-mass spectrometry, NMR, ultracentrifuge, cell culture facilities, small animal vivarium, and a cold storage room are available through collaboration with the departments of Biology and Chemistry.)

Molecular Pharmacology and Cell Biology Lab Panorama

Student-Directed Research

Numerous opportunities exist for student-directed research, including independent study, advanced practice rotations in research and/or academia, and laboratory teaching assistants. The following areas represent the variety of research being conducted in the department:

Dr. Ramil Sapinoro

  • POSTER PRESENTATION: Sapinoro, Ramil; Krasnov, Boris; Lombardozzi, Mathew; and Caraballo, Maria, "Programming macrophage inflammation-resolution: The role of omega-3 polyunsaturated fatty acids" - LIPID MAPS Annual Meeting: Lipidomics Impact on Cell Biology, Inflammation and Metabolic Diseases, La Jolla, CA, 2015
  • ORAL PRESENTATION: "Topic of the Day: Oral Vaccines and Other Clinical Trial Updates" in conjunction with the Rochester Victory Alliance - Rochester Area Task Force on AIDS (RAFTA) General Meeting, Rochester, NY, 2015

Dr. Amy Parkhill

  • J Hilbert, R Barohn, P Clemens, E Luebbe, W Martens, M McDermott, A Parkhill, R Tawil, C Thornton, R Moxley, III, on behalf of the National Registry Scientific Advisory Committee/Investigators. High frequency of gastrointestinal manifestations in myotonic dystrophy type 1 and type 2. Neurology (in press).
  • B Fitzgerald, K Conn, J Smith, A Walker, A Parkhill, J Hilbert, E Luebbe, R Moxley III, (2016). Medication adherence in patients with myotonic dystrophy and facioscapulohumeral muscular dystrophy. J Neurol.; 263(12):2528-2537.

Prof. Anthony Corigliano

  • POSTER PRESENTATION: Using Inter-professional Education as a means to enhance Personal and Professional development. AACP Annual Meeting, July 2015, Arlington, VA

Dr. Fang Zhao

  • M Caraballo, S Donmez, K Nathan, and F Zhao. Compounded apixaban suspensions for enteral feeding tubes. Pharm. Prepublished July 25, 2017, DOI: 10.1177/0018578717720507.
  • S Rush, C Vernak, and F Zhao. A pilot stability study of dehydroepiandrosterone (DHEA) rapid-dissolving tablets prepared by extemporaneous compounding. Int. J. Pharm. Compd. 21:83-87 (2017).

Dr. Lipika Chablani

  • Akalkotkar A, Chablani L, Tawde SA, D'Souza C, D'Souza MJ. Development of a microparticulate prostate cancer vaccine and evaluating the effect of route of administration on its efficacy via the skin. J Microencapsul. 2015;32(3):281-9. doi: 10.3109/02652048.2015.1017615.
  • Chablani L, Mulla N and D'Souza MJ. Mucosal delivery of particulate breast cancer vaccine. Nanoparticulate Vaccine Delivery Systems, Pan Stanford Publishing. 2015; May: 171-185.

Dr. Vivek S. Dave

  • Dave VS, Chanda M, Sayles M, Popielarczyk M, Boyce H, Bompelliwar SK, et al. Correlation of Structural and Macroscopic Properties of Starches with Their Tabletability Using the SM2 Approach. Journal of pharmaceutical sciences. 2015; 104 (11):3870-82. doi: 10.1002/jps.24601.
  • Dave VS, Saoji SD, Raut NA, Haware RV. Excipient variability and its impact on dosage form functionality. Journal of pharmaceutical sciences. 2015; 104 (3):906-15. doi: 10.1002/jps.24299.

Dr. Melinda Lull

  • Lull ME, Mathews JM. Online self-testing resources prepared by peer tutors as a formative assessment tool in pharmacology courses. Am J Pharm Educ 2016; 80(7): Article 124. [PMID: 27756932]
  • Seidel DP, DeNapoli SM, Maciulewicz TS, Lull ME. Fructose alters cell survival and gene expression in microglia and neuronal cells lines. Abstract #243147. American Society of Health Systems Pharmacy Midyear Clinical Meeting, Las Vegas, Nevada, December 2016.